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Patterns of Inheritance: Fruit Flies, Blood Types, Population Genetics and Hardy-Weinberg
Lab Overview
Over the next four weeks we will be working with two different exercises and simulations to further examine patterns of inheritance. In the first series of labs you will perform monohybrid and dihybrid crosses using real fruit flies (Drosophila melanogaster) to examine inheritance patterns. The labs are spread out over a course of four weeks due to the time it takes to cross and rear flies. The second set of labs deals with inheritance patterns of human blood types. During the “down time” of the fly lab, you are expected to work on the blood typing activity and become familiar with the genetics behind different blood types. You are also expected to become familiar with the Hardy-Weinberg principle, and how it can be used as a null model to determine if evolution has occurred in a population. Finally, you will perform computer simulations of population genetic processes during Week 6.
Lab Breakdown:
Week 4 Examination of wild-type and mutant Drosophila phenotypes and sex identification. Begin blood typing exercise.
Week 5 F1 phenotyping, setting up F1 crosses. Continue working on blood typing exercise.
Week 6 Remove all adult F1 flies from cross vials. Perform population genetic simulations.
Week 7 Score phenotypes of all F2 flies. Data analysis and review.
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