The client will continue to take methotrexate (MTX, Rheumatrex, Trexall) for treatment of…

The client will continue to take methotrexate (MTX,
Rheumatrex, Trexall) for treatment of osteosarcoma. When teaching the client
prior to discharge, what over-the-counter (OTC) drugs must not be taken
concurrently with methotrexate?

1. Nonsteroidal anti-inflammatory drug pain relievers

 2. Antihistamines

 3. Laxatives

 4. Cough suppressants